Settling into their new digs in San Francisco is about to become problematic for the X-Men . If the return of Madelyne Pryor ( Cyclops ' evil ex-wife) wasn't enough to contend with, Emma Frost 's is about to have an offer from Norman Osborn she really should refuse... [HOUSE OF M - The mutant population is decimated by the Scarlet WItch] [MANIFEST DESTINY - The X-Men move to San Francisco] [SECRET INVASION - Norman Osborn saves the planet] Uncanny X-Men #504-505 (also see MANIFEST DESTINY ) Secret Invasion: Dark Reign #1 (tie-in) (also see SECRET INVASION & DARK REIGN ) Uncanny X-Men #506-507 (also see MANIFEST DESTINY ) Uncanny X-Men Annual #2 (also see DARK REIGN ) Uncanny X-Men #504 Madelyne Pryor is back from the dead, operating as the ' Red Queen ' and recruiting Spiral and Lady Deathstrike to the ranks of her Sisterhood of Mutants . While struggling to get over losing Shadowcat in space (during UNSTOPPABLE ), Colossus runs into a Tattooed Man ...